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Each vial 150 mg and contains 21 mg/mL of trastuzumab, a humanized IgG1 monoclonal antibody expressed in Chinese hamster ovary cells.
Excipients/Inactive Ingredients: L-histidine, L-histidine hydrochloride, Trehalose dihydrate, Polysorbate 20.


Pharmacotherapeutic Group: Antineoplastic agents, monoclonal antibodies. ATC Code: L01XC03.
Pharmacology: Pharmacodynamics: Trastuzumab is a recombinant humanised IgG1 monoclonal antibody against the human epidermal growth factor receptor 2 (HER2). As per the published literature, in 20 %-30 % of primary breast cancers overexpression of HER2 is observed. Studies of HER2-positivity rates in gastric cancer (GC) using immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) or chromogenic in situ hybridization (CISH) have shown that there is a broad variation of HER2-positivity ranging from 6.8 % to 34.0 % for IHC and 7.1 % to 42.6 % for FISH. Studies also indicate that breast cancer patients whose tumours overexpress HER2 have a shortened disease-free survival compared to patients whose tumours do not overexpress HER2. The extracellular domain of the receptor (ECD, p105) can be shed into the blood stream and measured in serum samples.

Trastuzumab 150mg vial (Hertraz)

SKU: GSP-001
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